The Penn State Campus is located within driving distance of many major cities including Harrisburg (1.5 hrs., 90 mi), Pittsburgh (3 hrs., 137 mi), Philadelphia (3.5 hrs., 194 mi), Baltimore (3.5 hrs., 155 mi), Washington D.C. (4 hrs., 190 mi), New York City (5 hrs., 250 mi) and Toronto (6.5 hrs., 304 mi).

From New York City, the suggested route is via the George Washington Bridge to I-80. In Pennsylvania, exit I- 80 at exit 161 (Bellefonte) and follow PA Route 220 south to State College. Take exit 74 for Innovation Park/Penn State University. Continue on Park Ave. Take a left onto Atherton Street and continue to second light. At second light take a right onto White Course Drive and proceed around the bend to find parking.  The Applied Science Building is directly in front of the stop sign at the end of the bend.

From the Philadelphia area, take Philadelphia Schuylkill Expressway to the Pennsylvania Turnpike, leave the Turnpike at exit 247 (Harrisburg East), and follow I-283 to I-83 and proceed north on I-83 to the I-81 interchange. Then follow I-81 south to Route 322, 22 West exit. Proceed west on Route 322 through Lewistown to State College exit #74. Continue on Park Ave. Take a left onto Atherton Street and continue to second light. At second light take a right onto White Course Drive and proceed around the bend to find parking.  The Applied Science Building is directly in front of the stop sign at the end of the bend.

From Pittsburgh, follow Route 22 East to Duncansville, I-99/Route 220 North to Route 322 East to Mt. Nittany Expressway/State College exit #73,

OR

Follow Route 22 East beyond Duncansville to Water Street, Route 45 East to Pine Grove Mills and Route 26 North to State College.

From the west, take I-80 to exit 123 (Woodland) just east of Clearfield, then US Route 322 east to State College, or exit I-80 at exit 161 (Bellefonte) and follow PA Route 220 south to State College.

From Washington, D.C., take Route 270 to Frederick then Route 70 to Breezewood - PA turnpike (exit 12) - and go one exit West to Bedford (exit 11); Take I-99 north to Route 220 to Route 322 East to State College exit #74, continue on Park Ave. Take a left onto Atherton Street and continue to second light. At second light take a right onto White Course Drive and proceed around the bend to find parking.  The Applied Science Building is directly in front of the stop sign at the end of the bend.

OR

take I-95 or the Baltimore-Washington Parkway to Baltimore, west loop I-695 to I-83 north. Continue on I- 83 north to the I-81 interchange. Then follow I-81 south to Route 322, 22 exit. Proceed west on Route 322 to Lewistown and State College.